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Coordination Compounds of M(II) Biometal Ions with Acid- Type Anti-inflammatory Drugs as Ligands – A Review
Abstract
The cations of biometals in biological systems easily interact with various moieties of organic and inorganic biomolecules, either as natural constituents or after introduction into the body via O-, N- and S- donor atoms. Study of the interaction between M(II) biometal–O-donor ligand (drug) is of interest for various reasons: more evenly dosing of medicine and biodistribution of medicine; monitoring of its pharmacokinetics including excretion; reduction of unwanted effects of the medicine; greater antimicrobial activity; synergistic effect of the metal and medicine; and improved anti-ulcerous, antitumor and anti-bacterial activity. This paper offers an overview of the literature of published research on coordination between biometals and anti-inflammatory drugs of the acid type. The metals that the subject of focus in this review are d-metals with M(II) ions, namely, copper (Cu), zinc (Zn), cobalt (Co) and manganese (Mn).Those containing molecules with carboxyl functional groups can build complexes with coordinated number of metals of 4 and 6, of various stoichiometric structures, simple or complex, and also behave as monodentate, bidentate or bridge ligands in polynuclear complexes.
Keywords: Biometals M(II), Anti-inflammatory medicine, Coordination, O-Donor ligands, Copper, Cobalt, Manganese, Zinc
