Article Sidebar
DOI:
10.4314/tjpr.v14i2.4Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Development and In vitro Evaluation of Self-Adhesive Matrix-Type Transdermal Delivery System of Ondansetron Hydrochloride
Abstract
Purpose: To develop and evaluate self-adhesive matrix-type ondansetron hydrochloride (OND) transdermal formulation.
Methods: OND transdermal patches were prepared using solvent casting method. The matrix polymer composition was Eudragit E 100, polyvinyl pyrrolidone and either propylene glycol or dibutyl sebacate as plasticizer. Mean patch thickness, tensile strength, moisture content, water absorption capacity and drug content of the patches were studied. In vitro release and permeation of the patches were determined using Franz diffusion cell.
Results: Mean patch thickness, moisture content, and water uptake increased with increased contents of polyvinyl pyrrolidone (PVP) and plasticiser. Higher levels of PVP and plasticiser increased drug release. Addition of release modifier such as succinic acid (SA) and myristic acid (MA) to the patch formulations produced a significant increase in drug release from the patch. Higuchi plots for patches containing propylene glycol (PG) were non-linear (r2 = 0.9564), indicating that they did not follow Higuchi release model whereas the plots for most of the patches containing dibutyl sebacate (DBS) followed Higuchi release model (r2 = 0.9974).
Conclusion: DBS is a superior plasticiser to PG for OND matrix patches while succinic acid (SA) is a more effective release modifier than myristic acid (MA) for PG patches.
Keywords: Ondansetron hydrochloride, Drug release, Release modifier, Transdermal, Dibutyl sebacate, Succinic acid, Higuchi model, Plasticizer
