Article Sidebar
Published:
Dec 12, 2014Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Antidiabetic and hypolipidemic effects of methanol leaf extract of Napoleona vogelii (Lecythidaceae) Hook & Planch on alloxan–induced diabetes mellitus in rats
Abstract
Purpose: To evaluate the antihyperglycaemic and hypolipidemic effects of Napoleona vogelii Hook. & Planch (Lecythidaceae) methanol leaves extract in alloxan-induced diabetes in rats.
Methods: The leaves were extracted via cold maceration using 70 % methanol. Diabetes was then induced using alloxan (150 mg/kg I.P). Alloxan-induced diabetic rats were divided into 5 groups of 5 each and were treated with 100, 200 and 400 mg/kg of the methanol extract. The 4th and 5th diabetic groups were given glibenclamide (5 mg/kg) and distilled water respectively. The 6th group, normal rats were given distilled water. Treatment was continued daily and orally for 14 days. Blood glucose levels were monitored at 0, 2, 4, 8 and 24 h, and 14th days. The lipid profile was determined on the 14th day of administration. Oral acute toxicity and phytochemical screening were also carried out on the extract.
Results: The extract significantly (p < 0.05) reduce fasting blood glucose level at 100, 200 and 400 mg/kg notably from the 4th hour to the 14th day. The effect of the extract compared well with that of glibenclamide which also produced significant reduction (p < 0.05) in blood glucose level in the diabetic rats from the 4th hour onwards. The extract significantly increased and lowered (p < 0.05) High density lipoprotein (HDL)-cholesterol and Low density lipoprotein (LDL)-cholesterol + triglycerides), respectively, at 100 and 200 mg/kg doses. Total cholesterol was also significantly reduced (p < 0.05) at 200 and 400 mg/kg doses. Acute toxicity data revealed death at 4 g/kg dose. While phytochemical screening revealed the presence of flavonoids, saponins, glycosides, tannins and anthraquinones.
Conclusion: These data suggest that Napoleona vogelii leaves have potential hypoglycaemic effect and could be a useful source of an anti-diabetic agent.
Keywords: Napoleona vogelii, Lipid profile, Diabetes, Glibenclamide, Hypoglycemic effect
