Article Sidebar
Published:
Dec 12, 2014Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Accumulation of 99mTC-methylene diphosphonate radiotracer in rat's forelimb
Abstract
Purpose: To evaluate the efficacy and radioactivity counts of technetium-99m methylene
diphosphonate (99mTc-MDP) radiotracer by scintigraphy.
Method: In this study, 7 healthy Wistar rats were anesthetized. Technetium was milked from molybdenum-technetium generator and added to methylene diphosphonate (MDP) kit. Scintigraphic scans were carried out in several areas of the rat’s forelimbs by gamma camera 2 h after the injection of 99mTc-MDP via the tail vein. Accumulations of the radioisotope in the study areas were calculated using region of interest (ROI) technique.
Results: Mean count of radioisotope in the right and left sides of the shoulder area was 4179.29 and 4074.24, respectively; in the right and left sides of the elbow joint areas, the count was 1662.14, 1645.28, respectively. The count in the right and left sides of the carpal joint and finger areas was 1908.42 and 2028.28, respectively.
Conclusion: This study shows that 99mTc-MDP radiotracer can be used for survey radioactivity examination in different bones of the forelimb. Comparison of radioisotope counts in these areas can be used for the diagnosis of disease.
Keywords: Bone, Rat, Scintigraphy, Technetium, Methylene diphosphonate
