Article Sidebar
Article Details
The entire contents of the Tropical Journal of Obstetrics and Gynaecology are protected under Indian and international copyrights. The Journal, however, grants to all users a free, irrevocable, worldwide, perpetual right of access to, and a license to copy, use, distribute, perform and display the work publicly and to make and distribute derivative works in any digital medium for any reasonable non-commercial purpose, subject to proper attribution of authorship and ownership of the rights. The journal also grants the right to make small numbers of printed copies for their personal non-commercial use.
This journal content is distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
Main Article Content
A randomised controlled study of goserelin as adjunctive therapy prior to surgery in the management of uterine fibroids
Abstract
Objective: The aim was to assess the effects of depot injections of goserelin (Zoladex®), a GnRH-agonist analogue, on the management of uterine fibroids.
Patients and Methods: Forty female pre-menopausal patients aged between 26 and 50 years, with uterine sizes 12 to 26 weeks were enrolled in a randomised controlled study. One group was prospectively randomized to surgery (deferred for 0 to 4 months) and another to goserelin treatment for 3 months, followed by surgery. Patients were included if they had a diagnosis of benign uterine fibroids and an abdomino-pelvic mass greater than 12 weeks gestational size.
Results: Uterine and fibroids volumes were reduced by a median value of 31.7% and 58.1% respectively for Zoladex patients compared with an increase of 3.3% and 0.6% in uterine and fibroid volumes in the surgery-only patients. The difference between the treatment groups for the absolute changes was statistically significant (P<0.0001). Patients in the goserelin group had a somewhat higher haemoglobin level by the time of surgery compared to the time of entry (P=0.06), had an easier operation and a shorter stay in hospital. Adverse events were more numerous in the goserelin treated patients.
Conclusion: Goserelin treatment, prior to surgery, demonstrated benefit in terms of uterine and fibroids volumes, symptoms reduction and improvement of haematological profile in Nigerian patients with uterine leiomyoma.
Keywords: uterine fibroids, goserelin, adjunctive therapy, surgery
Tropical Journal of Obstetrics and Gynaecology Vol. 22(2) 2005: 120-124
