Main Article Content
Prevalence of helicobacter pylori infection among symptomatic subjects with dyspepsia at Nnewi
Abstract
Background: H. pylori infection has been linked to important gastroduodenal diseases in man. The impact of eradication therapy is frequently difficult to assess as antibodies remain long after eradication of the infection. These shortcomings not withstanding serological studies and stool antigen tests have been found useful in epidemiological studies.
Objective: To determine the frequency of H. pylori carriage and its associated factors among dyspeptic subjects at Nnewi.
Design: Cross sectional study.
Setting: NAUTH Medical Out Patient Department.
Methods: consecutively recruited subjects; Interviewer administered questionnaire; detection of antibody to H.pylori in blood (using SD
Bioline Kits supplied by JANSSEN-CILLAG Nig) using immunochromatographic methods.
Main Outcome measures: Antibody reactions in whole blood; associations between sociodemographic factors and immunochromatographic
antibody reactions.
Results: Sixty five subjects were consecutively studied, 20males and forty five females. 21 of the 65 subjects showed positive
immunochromatographic reactions. The tendencies to seek orthodox medical services were significantly associated with presence of alarm
symptoms among the subjects (X24.41 P< 0.05). Below 50yr males showed more positive antibody reactions while females predominated
beyond 50yrs (X26.28 P< 0.05). Eating meals cooked at home alone or supplemented with meals from the eateries did not influence the
immunochromatographic antibody reactions.
Conclusions: The prevalence of H.pylori in our dyspeptic subjects was lower than in other parts of Nigeria. Methodological differences not
withstanding. It is probably timely to advocate for multi centered country wide study to guide interventional measures in primary reaction.
Objective: To determine the frequency of H. pylori carriage and its associated factors among dyspeptic subjects at Nnewi.
Design: Cross sectional study.
Setting: NAUTH Medical Out Patient Department.
Methods: consecutively recruited subjects; Interviewer administered questionnaire; detection of antibody to H.pylori in blood (using SD
Bioline Kits supplied by JANSSEN-CILLAG Nig) using immunochromatographic methods.
Main Outcome measures: Antibody reactions in whole blood; associations between sociodemographic factors and immunochromatographic
antibody reactions.
Results: Sixty five subjects were consecutively studied, 20males and forty five females. 21 of the 65 subjects showed positive
immunochromatographic reactions. The tendencies to seek orthodox medical services were significantly associated with presence of alarm
symptoms among the subjects (X24.41 P< 0.05). Below 50yr males showed more positive antibody reactions while females predominated
beyond 50yrs (X26.28 P< 0.05). Eating meals cooked at home alone or supplemented with meals from the eateries did not influence the
immunochromatographic antibody reactions.
Conclusions: The prevalence of H.pylori in our dyspeptic subjects was lower than in other parts of Nigeria. Methodological differences not
withstanding. It is probably timely to advocate for multi centered country wide study to guide interventional measures in primary reaction.
