Pattern Of Biochemical Derangements Seen In Chronic Renal Failure Patients At Enugu

Abstract

Objective: To study the pattern of biochemical derangements in advanced renal failure patients.
Subjects and Methods: Ninety adult patients [54 males and 36 females] were recruited from the renal clinic of the University of Nigeria Teaching Hospital (UNTH) Enugu over a period of one year. History and physical examination was carried out on initial visit. This was followed by laboratory investigations, including serum urea and creatinine, twenty-four hour urinary creatinine estimation which were used to determine creatinine clearance. The subjects were then divided into three groups, depending on the glomerular filtration rate (GFR). Serum calcium, phosphate, total alkaline phosphatase and calcium- phosphate products were determined.
Results: The age range of the study population was from 16years – 65 years, with a mean of 38.22 ± 11.22 years. The peak age incidence of chronic renal failure (CRF) in both male and female subjects was in the 26year - 35 year age group. The lowest incidence was in the 56year - 65 year age group. Biochemical derangements especially serum alkaline phosphatase, phosphate and calcium- phosphate product were elevated in most of the subjects, especially those in sub group 3 [GFR ≤ 5ml/m].
Conclusion: Biochemical derangements are common especially in end stage CRF and should be looked for and managed intensively.


Keywords: Glomerular filtration rate, Chronic renal failure, Biochemical derangements, Enugu.

Tropical Journal of Medical Research Vol. 12 (1) 2008: pp. 32-37