Histopathological Review of Primary Bone Neoplasms in University of Ilorin Teaching Hospital, Ilorin, Nigeria

Abstract

Primary bone neoplasms are uncommon globally and have diverse morphological patterns that formed the basis for their classification. There is paucity of data on the incidence in the developing Countries including Nigeria. The aim of this review was to document the histological variants as well as age and sex distributions of all primary bone neoplasms reported in Department of Pathology, University of Ilorin Teaching Hospital between January 2006 and December 2016. Out of a total of 141 bone samples submitted to Pathology Department over the study period, 62 (44%) were reported as primary neoplasms. Twenty-eight (43.1%) cases of the primary neoplasms were benign, while 34 (56.9%) cases were malignant. There was slight male predominance for both benign and malignant neoplasms; 1.25:1 and 1.7:1 respectively. The peak age range and mean age for benign neoplasms are 11-20 years and 26.6 age ±14.2, while the peak age of occurrence and mean age for malignant neoplasms are 11-20 years and 27.1 years ± 17.7. Osteochondroma was the commonest benign bone neoplasms (37%) while osteosarcoma was commonest malignant counterpart (51.4%). Primary malignant bone neoplasms were commoner than benign bone neoplasms in our center; and both have male predominance and are mostly seen in patients below 30 years of age. Our study showed that Osteosrcoma as the commonest primary bone neoplasm.

Keywords: Primary bone neoplasms, review, histopathology, Ilorin