The analgesic, haematological and some physiological effects of extradural bupivacaine in healthy dogs

Abstract

The aim of this research is to investigate the analgesic, haematologic and some physiological effects of extradural bupivacaine on dogs using six clinically healthy adult male dogs. The method used is by obtaining baseline data for physiological variables from each dogs using the multiparameter patient monitors (GD3, GenaralMeditech, Inc, China). Blood sample were also collected from the cephalic vein after extradural administration of the drug. The onset of the analgesia was determined using pin prick and the quality of analgesia with pre scrotal  urethrectomy. The physiologic variables, pulse and respiratory rate including temperatures, blood pressure and oxygen saturation were recorded. Blood samples for heamatology were collected at 30 minutes intervals after the drug administration with the dog simultaneously undergoing pre scrotal urethrectomy for bladder stones removal for one hour. The onset of the action was 29±11.34 and the quality of analgesia was very good to excellent lasting for 128minutes. There was no significant difference in values of all the physiologic parameters except the ECG which showed significant level of arrthymia 30 minutes after the drug administration. We therefore conclude that epidural bupivacaine produces very good regional  analgesic for pre scrotal urethrectomy and safe in Nigerian local breeds of dogs.

Keywords: Analgesia, Extradural Bupivacaine, Haematology, Nigerian Local Dogs, Physiology