Sub-chronic Toxicological evaluation of extract of Lavandula stoechas on Liver, haematological parameters, and feed consumption of Wistar rats

Abstract

Introduction: Lavandula stoechasare commonly used to treat various medical ailments. This study aims to determine its toxicological impact on Wistar rats’ meal consumption, liver, and haematological markers.

Method: Animals of either sex were selected. Group 1 received normal saline (10 ml/kg), while groups 2, 3, and 4 received 50, 100, and 200 mg/kg, respectively, of Lavandula stoechas. The animals were kept in standard cages and given oral access to the extract for 28 days before being weighed and killed. A cardiac puncture was utilized to get blood, which was then immediately tested. The haematoxylin and eosin (H&E) staining technique evaluated the plant's histological hepatotoxic potential.

Result: Compared to the control, ethanol leaf extract of Lavandula stoechas generated a substantial (P<0.05) increase in body weight in the first, third, and fourth weeks but not in the second. There was a significant (P<0.05) drop in RBC, HGB, and MCV but no change in neutrophils, basophils, eosinophils, or platelets. At 100 mg/kg dose, Lavandula stoechas generated a substantial (P<0.05) rise in ALP and BILD. Other metrics did not differ substantially (P<0.05) across doses delivered. A histological examination revealed minor tubular deformation.

Conclusion: Though the plant is primarily safe, the study results show that it may have a minor effect on the liver, implying that it should be used cautiously for an extended period. A histological examination revealed minor tubular deformation.