Prevalence and antimicrobial resistant Escherichia coli and Klebsiella sp among individuals with urinary tract infection from hospital and community settings in Ado-Ekiti, Nigeria

Abstract

The antibiotic resistance of urinary pathogens has been varying over the period of years, in community and healthcare-associated infections. The study provided the current prevalence and antimicrobial-resistant Escherichia coli and Klebsiella sp among individuals with urinary tract infections from hospital and community settings in Ado-Ekiti, Nigeria. Midstream urine samples were collected and studied using standard microbiological techniques. Information for the factors associated with UTIs was obtained using questionnaires. An agar disc diffusion technique was used to test for antibiotic susceptibility. The chi-square test and Poisson regression was used to express associations among descriptive variables of UTI. The study revealed females are more susceptible to UTIs than males. Bacterial isolates showed a low prevalence of UTI with 122(8.5%). The age-wise distribution shows that the Incidence is more common in age bracket 51-60 and 21to 30 years. Gender and risk factors among the individuals had a significant relationship with UTIs. Overall, the bacterial strains showed the highest resistance to amoxicillin-clavulanate 43(91.5%) and most susceptible to imipenem 40(85.1%). The bacteria isolates also showed high multiple resistance with 0.6 MAR index. Appropriate diagnosis and management of UTI are aimed at treating the acute occurrence as well as preventing recurrences of this infection.