Cardio Protective Effect of Solanum nigrum Linn. in Isoproterenol Induced Myocardial Infarction in Rat

Abstract

Myocardial infarction is one of the highest confronting metabolic syndromes which cause
morbidity and mortality across the world. Recently, the renewed interests in medicinal
plants have certain preventive action in treatment of cardiovascular disorder. The aim of
the study was to investigate the cardio protective effects of Solanum nigrum Linn (hydro
alcoholic extract) in isoproterenol induced myocardial infarction. The extracts were
investigated for in vivo cardio protective activity; the rats were pre treated with hydro
alcoholic extract (75mg, 150mg and 300mg) for a period of 21 days. Standard drug
(carvedilol - 2mg/kg) was used to compare the results with various parameters like
bodyweight, ECG, heart weight, serum parameters and enzyme estimation. The rats fed
with extracts showed dose dependent cardio protective activity. Isoproterenol treated
animals showed a marked increase in serum marker enzymes such as CK-MB, LDH,
cholesterol, triglycerides, SGOT, SGPT. It was also observed that there was substantial
increase in heart and body weight along with endogenous enzyme levels of LPO. There
was significant decrease in levels of SOD, CAT and GSH. Treatment group significantly
reduced the effects of isoproterenol induced myocardial infarction. Solanum nigrum hydro
alcoholic extract treated groups possess cardio protective effect against isoproterenol
induced myocardial infarction.