Acetylcholinesterase Inhibitory Activity of Green Tea Polyphenols

Abstract

Inhibition of acetylcholinesterase activity is one of the most popular approaches for treatment of neurological disorders such as Alzheimer’s  disease and others. In the present study, we evaluated inhibition of  acetylcholinesterase activity by different concentrations of green tea (Camellia sinensis L.) extract using acetylthiocholine as substrate. The green tea extract inhibited AChE activity dose dependently with an IC50 value of 42.05µg/ml. The observed inhibitory activity could be ascribed to the polyphenolic content of green tea extract. Consumption of green tea might provide protection against neurological disorders.