Synthesis of novel sulfonamide derivatives containing phthalimide moiety

Abstract

An efficient and eco-friendly green methodology is developed for the synthesis of novel sulfonamide derivatives from sulfanilamide and phthalic  anhydride in ethanol as a solvent, using ultrasound irradiations. Higher yield, shorter reaction time, green conditions and optimization with the design of  experiment are the major advantages of this method. The structures of the synthesized compounds were carefully characterized by 1H, 13C NMR as well  as IR.