Effect of sodium selenite on sub-acute paraquat-induced toxicity in male rats

Abstract

Acute paraquat (PQ) toxicity induces redox cycling leading to fatality in both man and animals with clinical management being supportive therapy due to lack of specific and effective antidote. This study thus aimed at determining the sero-biochemical and pathological changes induced by acute PQ administration in male rats and the mitigating role of sodium selenite. Forty male rats were used for the study and were grouped into 5 of eight rats viz: Group I (control) administered distilled water (2 ml/kg), group II (15 mg/kg of PQ), group III (15 mg/kg of PQ + 0.3 mg/kg sodium selenite), group IV (30 mg/kg of PQ) and group V (30 mg/kg of PQ + 0.3 mg/kg sodium selenite). Administration were achieved per os and lasted for a week. Sera, lungs, liver and kidney samples were harvested at the end of the experiment. Result showed a significant (p < 0.05) higher liver enzymes, urea and creatinine in treated groups when compared to control. Biomarkers of oxidative stress revealed a significant (p < 0.05) increased superoxide dismutase and malondealdehyde activities of the lungs and liver. A dose-dependent pathologic lesion was also observed with milder lesions in selenium supplemented groups. The results demonstrate that selenium supplementation may be a promising therapy and should further be clinically validated.