Alterations in the lipid profile and liver enzymes of rats treated with monosodium glutamate

Abstract

This study was carried out to evaluate the effects of monosodium glutamate on the liver and lipid profile of eighteen adult male Wistar rats as measured by biochemical parameters. The rats received monosodium glutamate at dose rate of 0, 0.5 and 1.0g per day for 28 days. There was significant increase (P<0.05) in aminotransferases i.e. alanine and aspartate aminotransferases as well as increase in total plasma cholesterol and low density lipoprotein cholesterol most obvious at higher dose of 1.0g of monosodium glutamate. Though there was decrease in plasma protein concentration, triglyceride and high density lipoprotein cholesterol which was not statistically significant, therefore monosodium glutamate has both hepatotoxic and dyslipidaemia effects due to its alterations in both aminotransferase activities and lipid profile, hence monosodium glutamate though a flavor enhancer food additive but it must be carefully used in food preparation due to it alterations in both the liver enzymes and the lipid profile.

Keywords: Adult rats, dyslipidaemia, flavor enhancer, hepatotoxic, monosodium glutamate