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Dec 6, 2024Keywords:
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Sokoto Journal of Medical Laboratory Science (SJMLS) is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The journal holds the copyright for all the published articles. The signed copyright form submitted by the authors is a publication agreement between the journal and the authors.
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B Cell signaling and immunosuppression in geriatrics: A review
Abstract
The human immune system undergoes significant changes with age, leading to a phenomenon termed immunosenescence- A decline in immune functionality. This decline in immune function is characterized by a diminished ability to respond to novel antigens and increased susceptibility to infections. B cells, responsible for antibody production and humoral immunity, are particularly affected by immunosenescence. This review explores the intricate interplay between B cell signaling pathways and the development of immunosuppression in the elderly. It also discusses the alterations in B cell receptor (BCR) signaling, co-stimulatory molecules, and the influence of the inflammatory environment on B cell function. Additionally, the impact of chronic co-morbidities prevalent in geriatrics on B cell signaling was examined. Finally, the potential therapeutic strategies to rejuvenate B cell responses secondary to an enhanced vaccine efficacy in older adults was examined.
