Evaluation of coagulation factors seven (FV11) And twelve (FX11) in post intensive phase of Tuberculosis Disease Treatment in Bayelsa State, Niger

Abstract

Tuberculosis, a major health concern and leading infectious disease in man, is caused by Mycobacterium tuberculosis. Research shows that Tuberculosis affects the coagulation factors and causes elongated Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) in infected subjects. This research was conducted to evaluate coagulation factors VII and XII, in TB disease and treatment. Three facilities in Bayelsa State were used. Fifty newly diagnosed Tuberculosis subjects and fifty apparently healthy controls were studied. Tuberculosis subjects were monitored at two months intervals of treatment until the sixth month. Sputum was used for assay of Tuberculosis using Ziehl-Neelsen Technique and the GeneXpert, and plasma for PT and APTT assay. FVII and FXII were analysed using OPSY-MR Enzyme Linked Immunosorbent Assay machine using reagents from Glory Science Inc. (China). Statistical product for service solution (SPSS) software version 25 was employed in the data analysis. A p-value of <0.05 was considered significant. Results show significantly higher PT and APTT values but significantly lower FVII value in newly diagnosed Tuberculosis subjects compared to the control group. There was no significant difference in FXII (p>0.05) in new Tuberculosis subjects compared to controls. These results indicate that Tuberculosis disease altered all the parameters studied except coagulation factor XII. However, all altered parameters returned to almost control values at the end of the fourth month of treatment. We conclude from this study that the reduced values of FVII contribute to the elongation of PT in Tuberculosis patients while FXII is not altered and so does not contribute to the elongated APTT in Tuberculosis patients.