Protective potential of Momordica. charantia against CCl4 induced change in liver and kidney serum biomarkers in Wistar rats

Abstract

Mormodica charantia anti-inflammatory and antioxidant properties are regarded as crucial factors in reducing liver damage and fibrosis. Fibrosis, inflammation, and apoptosis are the hallmarks of acute liver injury, which can result in liver failure, cirrhosis, or cancer and have an impact on the clinical outcome over the long term. The medicinal value of M. charantia is derived from its bioactive phytochemical components, which have observable physiological effects on the body and act as a preventive measure. The aim of this present study was to investigate the effects of M. charantia on acute liver and kidney injury induced by carbon tetrachloride (CCl₄) in Wistar rats. Wistar rats were subjected to intraperitoneal injection of 1 ml/kg body weight CCl₄ with or without M. charantia (100 mg/kg, 200 mg/kg, and 300 mg/kg). Rats treated with CCl₄ developed acute liver and kidney injury, as evidenced by elevated levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), urea, creatinine, and accompanied with histological analysis. The present study highlighted that M. charantia exhibited liver and kidney protective effects against acute hepatic injury induced by CCl₄ via suppressing inflammation and oxidative stress. Administration of M. charantia demonstrated significant hepatoprotection and renal protection against CCl₄-induced liver and kidney injury in Wistar rats.