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May 29, 2023Keywords:
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Sokoto Journal of Medical Laboratory Science (SJMLS) is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The journal holds the copyright for all the published articles. The signed copyright form submitted by the authors is a publication agreement between the journal and the authors.
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Significance of Pseudomonas aeruginosa efflux pump system in antibiotic resistance
Abstract
Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen with a high morbidity andmortality rate in immunocompromised and cystic fibrosis patients. The treatment of P. aeruginosa infections is becoming increasingly difficult due to the bacteria's capacity to tolerate numerous antimicrobial agent. One of the key mechanisms of antimicrobial resistance (AMR) in P. aeruginosa that contributes to both innate and acquired resistance is the efflux pump system Understanding the structure, function, and control of the main efflux pump system, specifically the resistance nodulation division superfamily, iscritical. This could provide baseline data for the development of a new antibacterial that targets this crucial resistance pathway in P. aeruginosa, thereby halting or slowing morbidity and death associated with AMR.
