Possibility of Xanthine Oxidase and Malondialdehyde as a marker for Myocardial Infarction

Abstract

Background: the serum markers of myocardial injury are used to help in establishing the diagnosis of myocardial infarction.
Objective: to measure the levels of xanthine oxidase activity and malondialdehyde in myocardial infarction patients.
Methods: 100 patients with myocardial infarction and 50 healthy persons were included in this study. Xanthine oxidase activity assayed according to the method described by bergmeyer, h.u. while malondialdehyde (MDA) estimation was carried by thiobarbituric acid (TBA) based colorimetric method.
Results: significant increasing levels of xanthine oxidase activity and malondialdehyde were found in the blood of the patients with myocardial infarction when compared to healthy persons.
Conclusions: we propose the measurement of the blood levels of xanthine oxidase as a marker of myocardial infarction.