Antibodies against Merozoite Surface Protein 1 and 2 in Sudanese children

Abstract

Background: Malaria is a serious childhood disease causing high morbidity and mortality despite control measures. Immunological control against malaria was initiated early, and immunity acquired by children in endemic areas, which is age and exposure dependant, differs in different endemic settings. The objective of the study was to determine antibodies against Merozoite surface protein-1 (MSP-I) and Merozoite surface protein-2 (MSP-2), and to determine their relation to the age of Sudanese children. Methodology: The study was descriptive, cross-sectional, conducted in Khartoum Children Emergency Hospital (KCEH). 150 children with positive blood films for P. falciparum malaria were classified according to age, and a blood sample was taken from each one, and tested for antibodies against MSP-I and MSP-2. Results: Antibodies to MSP-I and MSP-2 were 46% and 42% respectively. Sero-positivity and sero-negativity for both antigens were 26.6% and 42.7% respectively. Seropositivity to either MSP2 or MSP1antigen alone was present in 18.7% and 12% of patients respectively. High seropositivity (52.9%) was found in the age group 12-15 years of age. Conclusion: MSP-1 and MSP-2 antibodies in Sudanese children according to this study were age dependant, and findings were similar to what had been reported in some African countries.

Key words: P. falciparum malaria, MSP-I, MSP-2.