Lansoprazole as part of triple therapy in eradication of H. pylori in Sudanese patients with gastro-duodenal inflammation

Abstract

Background: Eradication of H. pylori is important goal in the management of
uncomplicated peptic ulcer disease and other conditions associated with H.pylori. The
survival capabilities of H. pylori in the stomach makes it difficult to eradicate and effective treatment requires multidrug regimens.
Objectives: To study the efficacy of lansoprazole, Amoxicillin and metronidazole in the
eradication of H. pylori.
Methods: A total of 35 patients (22 males and 13 females) with gastro-duodenal inflammation and positive for H. pylori were studied. Gastro-duodenoscopy was repeated four weeks after completion of treatment to assess the healing of inflammation. Biopsies were taken from the stomach and tested for H. pylori before and after treatment.
Results: Twenty eight patients (93%) reported improvement in symptoms.
Eradication of H. pylori was confirmed with negative rapid urease test in 20(67%) patients. Complete healing of the gastro-duodenal inflammation was achieved in 22 patients (73%), partial healing in 6 patients, while only 2(7%) patients showed no healing.
Conclusion: The reduced eradication rate of this drug combination in this study (67%) compared to a previous one (96%) could be explained partly by the development of antibiotic resistance (possibly to metronidazole) during the last few years.

Keywords: ulcer, urease, endoscopy, metronidazole.

Sudan Journal of Medical Sciences Vol. 3 (1) 2008: pp. 41-44