Hepatoprotective Potentials Of Hibiscus rosasinensis Petal anthocyanin Extracts Against Carbon tetrachloride-Induced Acute Liver Damage in Wistar Rats.

Abstract

Carbon tetrachloride (CCl4) is haloalkane that possesses a hepatotoxic effect.
Material and Methods: The impact of anthocyanin fractions obtained from Hibiscus rosasinensis petal on carbon tetrachloride (CCl4) induced acute liver
damage in wistar rats was studied using a combination of alanine transferase
(ALT) activity value and liver: body weight gain ratio as indices.
Results: CCl4 treatment significantly increased both ALT value and the liver:
body weight gain ratio at the 1% probability level when compared with the
control values.
Conclusion: Pre-treatment with the anthocyanin fractions reduced the levels of these markers and hence, the degree of liver damage, though with varying potentials. The lead precipitated, non slimy red fraction possessed the greatest protective property on the rat liver when compared with the other anthocyanin fractions so tested.

Keywords: Anthocyanin, carbon tetrachloride, alanine transferase, Hibiscus rosasinensis, liver damage.

Sudan Journal of Medical Sciences Vol. 3 (1) 2008: pp. 33-36