Expression of Estrogen and Progesterone Receptors among Sudanese Women with Breast Cancer: Immunohistochemical Study

Abstract

Study design: This is a descriptive study to detect the level of Estrogen (ER) and Progesterone (PR) receptors in a
sample of biopsies from Sudanese women with breast cancer presented at Khartoum teaching Hospital
Material and Methods: Forty biopsies from breast cancer patients were examined with immunostaining
using anti-sera to ER and PR as markers to detect receptors.
Results: All the specimens showed the typical histopathologic features of breast cancer. Immunoreactivity testing
revealed positive ER in thirty-six patients (90%) and positive PR in thirty-one patients (77.5%). Of the 36 ER positive
samples, staining intensity was: strong in 20 (55.5 %) moderate in 10 (27.7 %) and weak in 6 (16.7 %). Of the 31 PR
positive samples, 15 (48.4 %) showed strong staining, 7 (22.5 %) moderate and 9 (29.0 %) weak staining
Conclusion: the studied specimens showed high level of positive ER and PR receptors

Sudan Joural of Medical Studies Vol. 2 (1) 2007: pp. 5-6