High sensitive c reactive protein as predictor marker for cardiovascular diseases in Sudanese type 2 diabetic patients

Abstract

Background: type 2 diabetes mellitus is frequently associated with inflammatory condition that lead to chronic complications. hs-CRP level had been reported as markers of cardiovascular diseases (CVDs) complications. Therefore, the aim of this study was to assess hs-CRP level in type 2 DM patients and their relation to diabetes cardiovascular complications.

Materials and methods: In case control study (205) diagnosed type 2 DM patients and (100) controls were included. Serum high Sensitive C Reactive Protein (hs-CRP), Triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL-C) and low density lipoprotein (LDL-C) were measured.

Results: Type 2 DM patients had increased level of hs-CRP and decreased HDL-C level p-value (0.020 and 0.000) respectively. Females had increased serum hs-CRP, TC, HDL-C and LDL-C p-value (0.005, 0.000, 0.000 and 0.000) respectively. Moreover, patients received statin drugs showed decreases in hs-CRP, TC and LDL-C p-value (0.030, 0.000 and 0.000) respectively. BMI correlate positively with TG (r: 0.37, P-value 0.017) and hs-CRP (r: 0.56, P-value 0.000), while it correlated negatively with HDL-C (r: -0.36, P-value 0.029).

Conclusion: The data suggested that, hs-CRP is useful diagnostic and predictor marker for CVDs in obese type 2 DM patients.

Keywords: High sensitive C reactive protein, cardiovascular diseases, type 2 DM, obesity, Sudan