Anticonvulsant Activity of Capsicum Annum (Red Pepper) Fruit Extract using Pentylentetrazole and Maximum Electroshock Induced Seizure Tests in Rats

Abstract

Background: Epilepsy is a disorder of brain function characterized by periodic and unpredictable occurrence of seizures that refers to as a transient alteration of behavior due to disordered, synchronous and rhythmic firing of populations of brain neurons. Modern drug therapy of epilepsy is complicated by side effects and inability to control seizures in some patients.
Objectives: The present study was conducted to test the anticonvulsant activity of Capsicum annum fruit extract in rat models.
Materials and Methods: The methanolic extract of Capsicum annum fruit was tested for its potential anticonvulsant activity using pentylentetrazole (PTZ) and maximum electroshock (MES) induced seizure models in rats. The simple activity meter was used to determine the sedative activity of Capsicum annum fruit extract. Thereafter, the protective index was calculated.
Results: Results obtained showed that the extract at concentrations of 5, 9, 10, 20 and 40 mg/kg produced dose dependent anticonvulsant activity. Capsicum annum (40 mg/kg, i.p.) caused 100% protection from seizure induced by PTZ and sedation in 50% of rats (TD50). Fifty percent anticonvulsant activity was produced by 9mg/kg Capsicum annum. Moreover, the protective index was calculated to be more than four. When tested on seizure induced by MES, Capsicum annum extract at doses of 10, 20 and 40 mg\kg showed no seizure protection.
Conclusion: It could be concluded that Capsicum annum fruit could be a source for potential antiepileptic agent(s). Further studies are needed to determine the active constituents responsible for the anticonvulsant activity as well as to elucidate their mechanism(s) of action.

Key words: Epilepsy, Pentylenetetrazole, electroshock, Capsicum annum, Sudan.