Effet antihypertensif d\'un extrait aqueux d\'écorce de tronc de Parkia biglobosa (mimosaceae) sur la pression artérielle de lapin.

Abstract

Un extrait aqueux des écorces de tronc de Parkia biglobosa (EAPB), à des concentrations comprises entre 1,18 et 18, 93 mg/kg de poids corporel, induit une hypotension dose dépendante sur la pression artérielle de lapin. L'interaction Adrénaline - EAPB a révélé une réduction significative (P<0.01) de l'hypertension induite par l'adrénaline. Cette action de EAPB ressemble à celle induite par le propranolol, un bloqueur des récepteurs ß adrénergiques ou encore à celle de la nifédipine, un anticalcique à prédominance vasculaire. Il a donc été conclu que l'action hypotensive de EAPB pourrait être due à une inhibition à la fois des récepteurs ß adrénergiques et de
l'influx calcique.
An aqueous extract of Parkia biglobosa (AEPB), at concentrations ranging from 1,18 to 18,93 mg/kg of body weight, decreased in a dose-depend manner the rabbit blood pressure. Adrenaline - AEPB interaction showed that AEPB was able to reduce significantly (P<0.01) adrenaline induced hypertension. The effect of AEPB was similar to that produced by propranolol, a beta-adrenoceptor blocker or by nifedipine, a calcium blocker. It was concluded that hypotensive action of AEPB could be due to beta-adrenoceptors blocker and may also imply a calcium blocker like effect.
An aqueous extract of Parkia biglobosa (AEPB), at concentrations ranging from 1,18 to 18,93 mg/kg of body weight, decreased in a dose-depend manner the rabbit blood pressure. Adrenaline - AEPB interaction showed that AEPB was able to reduce significantly (P<0.01) adrenaline induced hypertension. The effect of AEPB was similar to that produced by propranolol, a beta-adrenoceptor blocker or by nifedipine, a calcium blocker. It was concluded that hypotensive action of AEPB could be due to beta-adrenoceptors blocker and may also imply a calcium blocker like effect.
Keywords: i>Parkia biglobosa , adrenaline, nifedipine, propranolol, hypotension, antihypertensive properties.

Sciences & Nature Vol. 5 (2) 2008: pp. 133-143