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Trial of a new antirheumatic agent


I.F. Anderson

Abstract

A double-blind crossover trial of fenoprofen calcium versus acetylsalicylic acid (aspirin) and placebo in 10 outpatients with active rheumatoid arthritis, is reported. Both fenoprofen and aspirin were found to be similarly effective agents in rheumatoid arthritis with an average dose of 2,1 g fenoprofen compared with 4,5 g aspirin. No significant changes in selected laboratory tests were observed with either drug. The patients reported twice as many side-effects with aspirin; in fact, no drug-related side-effects could be attributed to fenoprofen itself. It is concluded that fenoprofen is a valuable and safe addition to the rheumatologist's armamentarium.

S. Afr. Med. J., 48, 899 (1974).

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eISSN: 2078-5135
print ISSN: 0256-9574