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Creatine excretion in diabetes mellitus
Abstract
Dupuytren's contracture is a common condition in diabetes mellitus. One of the authors has described 120 of these cases among 381 diabetics in the older age group. Steinberg has stated that in Dupuytren's contracture the creatine excretion in the urine is increased and suggests that both in this condition and in fibrositis there is an abnormality in tissue metabolism. He found that the total amount of creatine excreted per 24 hours in cases of primary fibrositis was 264-918 mg. (in this group he included Dupuytren's contracture). In 12 out of 15 cases it was over 300 mg. per 24 hours. In view of this suggestion and the frequency of Dupuytren's contracture in diabetes, it was decided to investigate the creatine excretion in a series of diabetic patients.
