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Clinical Evaluation of a New Non-depolarising Muscle Relaxant
Abstract
Certain pharmacological effects of a new non-depolarising muscle relaxant, AH 8165 (Glaxo), were studied in 50 patients. The adequate dose for muscle relaxation onset of action, duration of effect and reversibility with cholinesterase agents, were established. Changes in blood pressure, heart rate, intra-ocular pressure, blood gases and acid-base values were measured. In comparison with pancuronium bromide, the onset of action was much more rapid, but the duration of effect was the same. Reversal with anticholinesterase agents was good, and no residual hypoventilation could be detected postoperatively.
