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Hypercholesterolaemia and Atherosclerosis Induced in Vervet l\'lonkeys by Cholesterol-free, Semisynthetic Diets
Abstract
Vervet monkeys (Cercopithecus aethiops pygerethrus) were fed diets containing 40% carbohydrate, 25% casein and 14% hydrogenated coconut oil for 6 months. Three carbohydrates were fed: glucose, fructose and sucrose. All three diets were cholesterolaemic, the most severe cholesterolaemias being observed in the fructose and sucrose groups. All diets led to aortic sudanophilia. The fructose diet resulted in the most severe atherosclerosis and sudanophilia. This study' demonstrates the feasibility of using semisynthetic, cholesterol-free diets for the induction of hyperlipaemia and atherosclerosis in monkeys.
