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Drug-Induced Heart Failure in Advanced Pulmonary Tuberculosis
Abstract
Advanced cases of pulmonary tuberculosis with congestive cardiac failure had been found to carry a high mortality when treated with streptomycin, isoniazid and ethionamide, so a trial was designed to assess the value of using an alternative regimen, consisting of kanamycin and ethambutol. Results showed a highly significant difference between the two regimens in favour of the latter. Rifampicin in place of kanamycin appeared to be rather less effective in reducing mortality of these patients.
