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Pharmacology and Toxicology of Metiamide, a Histamine H2 - Receptor Antagonist
Abstract
A brief review of the pharmacology and toxicology of metiamide, a histamine H2-receptor antagonist, is given, and evidence is presented to support the view that it inhibits gastric acid secretion by virtue of its H2-receptor antagonist activity. Studies are also reported which show that metiamide given either intravenously or intraduodenally inhibits histamine- or pentagastrin-stimulated acid secretion in human subjects.
