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Initial Responses of Oedematous Patients to Furosemide and 81520
Abstract
Fifteen oedematous patients were treated with furosemide 40 mg b.d., or S1520 30 or 50 mg daily. Similar responses in mass loss, urinary output and electrolyte excretion occurred, but S1520 had a more profound effect on arterial blood pressure than furosemide. S1520 administration, in the dosage under consideration, may result in elevation of blood uric acid and glucose levels and also hypokalaemia, unless adequate potassium replacement is given.
