Article Sidebar
Article Details
Copyright remains in the Author’s name. The work is licensed under a Creative Commons Attribution - Noncommercial Works License. Authors are required to complete and sign an Author Agreement form that outlines Author and Publisher rights and terms of publication. The Agreement form should be uploaded along with other submissions files and any submission will be considered incomplete without it [forthcoming].
Material submitted for publication in the SAMJ is accepted provided it has not been published or submitted for publication elsewhere. Please inform the editorial team if the main findings of your paper have been presented at a conference and published in abstract form, to avoid copyright infringement. The SAMJ does not hold itself responsible for statements made by the authors.
Previously published images
If an image/figure has been previously published, permission to reproduce or alter it must be obtained by the authors from the original publisher and the figure legend must give full credit to the original source. This credit should be accompanied by a letter indicating that permission to reproduce the image has been granted to the author/s. This letter should be uploaded as a supplementary file during submission.
Main Article Content
Observations on the Effects of a New Diuretic-S1520
Abstract
S1520, a sulphonamide-derived diuretic, was administered to healthy volunteers and patients with oedema. A therapeutic effect was produced by doses of 10 - 20 mg. The onset of action was within 3 hours and persisted for up to 36 hours. Natriuresis, chloruresis and increasing kaliuresis were observed with continued administration. The probable site of drug action was on the distal tubule. Patients with severe renal failure or hyponatraemia did not show a therapeutic response, and the maximal efficacy of the drug was considered to be less than that of furosemide.
