Article Sidebar
Article Details
Copyright remains in the Author’s name. The work is licensed under a Creative Commons Attribution - Noncommercial Works License. Authors are required to complete and sign an Author Agreement form that outlines Author and Publisher rights and terms of publication. The Agreement form should be uploaded along with other submissions files and any submission will be considered incomplete without it [forthcoming].
Material submitted for publication in the SAMJ is accepted provided it has not been published or submitted for publication elsewhere. Please inform the editorial team if the main findings of your paper have been presented at a conference and published in abstract form, to avoid copyright infringement. The SAMJ does not hold itself responsible for statements made by the authors.
Previously published images
If an image/figure has been previously published, permission to reproduce or alter it must be obtained by the authors from the original publisher and the figure legend must give full credit to the original source. This credit should be accompanied by a letter indicating that permission to reproduce the image has been granted to the author/s. This letter should be uploaded as a supplementary file during submission.
Main Article Content
Maprotiline and Amitriptyline in the Treatment of Depressive Illness
Abstract
Patients suffering from depressive illness were admitted to a double-blind trial comparing the efficacy and tolerability of maprotiline and amitriptyline. Therapeutic efficacy was evaluated by means of the Hamilton Rating Scale for Depression (day 0, 3, 7, 14, 21, 28) and by the over-all assessments of investigator and patient at the end of the treatment. Tolerability and side-effects were evaluated by an over-all assessment and by a checklist of treatment signs and symptoms. Maprotiline was found to be markedly faster in its effect than amitriptyline. The effect of maprotiline was apparent in the majority of cases by the 4th day of treatment. The over-all improvement of patients on maprotiline was better than it was in those treated with amitriptyline, although this did not quite reach statistical significance. Tolerability was generally similar although it tended to favour maprotiline.
