Main Article Content

Effect of burimamide on histamine- and pentagastrin-stimulated acid and pepsin secretion in the pig


GO Barbezat
MW Waterworth
M Daniel
S Bank
J Terblanche

Abstract

Burimamide, a specific histamine H2-receptor antagonist, is an effective inhibitor of histamine and pentagastrinstimulated gastric acid secretion in the innervated pig stomach. Pepsin secretion, and acid secretion from denervated gastric pouches, were not significantly depressed by burimamide in the dose used in this study. Atropine inhibited pentagastrin- but not histaminestimulated gastric acid secretion from the innervated and denervated portions of the pig stomach.

S. Afr. Med. J., 48, 1985 (1974).

Journal Identifiers


eISSN: 2078-5135
print ISSN: 0256-9574