Copyright remains in the Author’s name. The work is licensed under a Creative Commons Attribution - Noncommercial Works License. Authors are required to complete and sign an Author Agreement form that outlines Author and Publisher rights and terms of publication. The Agreement form should be uploaded along with other submissions files and any submission will be considered incomplete without it [forthcoming].
Material submitted for publication in the SAMJ is accepted provided it has not been published or submitted for publication elsewhere. Please inform the editorial team if the main findings of your paper have been presented at a conference and published in abstract form, to avoid copyright infringement. The SAMJ does not hold itself responsible for statements made by the authors.
Previously published images
If an image/figure has been previously published, permission to reproduce or alter it must be obtained by the authors from the original publisher and the figure legend must give full credit to the original source. This credit should be accompanied by a letter indicating that permission to reproduce the image has been granted to the author/s. This letter should be uploaded as a supplementary file during submission.
Author Biographies
BA Bradlow
Department of Haematology, School of Pathology, University of the Witwatersrand and South African Institute for Medical Research, Johannesburg
C Saunders
Department of Haematology, School of Pathology, University of the Witwatersrand and South African Institute for Medical Research, Johannesburg
P Whitebread
Department of Haematology, School of Pathology, University of the Witwatersrand and South African Institute for Medical Research, Johannesburg
A Lurie
Department of Haematology, School of Pathology, University of the Witwatersrand and South African Institute for Medical Research, Johannesburg
GK Penford
Department of Haematology, School of Pathology, University of the Witwatersrand and South African Institute for Medical Research, Johannesburg
J Metz
Department of Haematology, School of Pathology, University of the Witwatersrand and South African Institute for Medical Research, Johannesburg
Main Article Content
Standardisation of the laboratory control of anticoagulant therapy
BA Bradlow
C Saunders
P Whitebread
A Lurie
GK Penford
J Metz
Abstract
The sensitivity of human and rabbit brain thromboplastin preparations to the coumarin-induced plasma defect was compared with the British comparative thromboplastin (BCn. The human thromboplastin yielded prothrombin ratios that compared favourably with those obtained with the BCT. Furthermore, the dose of anticoagulant required to maintain a prothrombin ratio in the therapeutic range was approximately similar whether the local human brain thromboplastin or the BCT was used. Rabbit brain preparations showed considerably less sensitivity to the coumarin defect. A stable suspension of human brain thromboplastin for use as a local standard was prepared and is available to laboratories in South Africa.
S. Afr. Med. J., 48, 1857 (1974).
Donate
AJOL is a Non Profit Organisation that cannot function without donations.
AJOL and the millions of African and international researchers who rely on our free services are deeply grateful for your contribution.
AJOL is annually audited and was also independently assessed in 2019 by E&Y.
Your donation is guaranteed to directly contribute to Africans sharing their research output with a global readership.
Once off donations here:
For annual AJOL Supporter contributions, please view our Supporters page.
Tell us what you think and showcase the impact of your research!
Please take 5 minutes to contribute to our survey so that we can better understand the contribution that African research makes to global and African development challenges. Share your feedback to help us make sure that AJOL's services support and amplify the voices of researchers like you.