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Aspects of Experimental Hepatocarcinogenesis
Abstract
This article describes the changes in the liver which followed withdrawal of the carcinogen p-dimethylaminoazobenzene (P-DAB) after it had been fed to rats for 20 weeks. The cirrhotic changes regressed virtually completely, but glycogen storage was greatly reduced and small hyperplastic areas persisted. Several carcinomas developed in these livers as long as 5 months after carcinogen feeding was discontinued. Ultrastructural changes observed in the non-neoplastic liver included nucleolar hypertrophy, an increase in the smooth endoplasmic reticulum and abnormalities of mitochondria. The possibility that these findings may have a bearing on the occurrence of primary liver cancer in non-cirrhotic patients in high-incidence areas is considered.
S. Afr. Med. J. 48, 1331 (1974).
S. Afr. Med. J. 48, 1331 (1974).