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Aspects of Experimental Hepatocarcinogenesis


AH Timme

Abstract

This article describes the light and electron microscopic features of 4 well-differentiated hyperplastic nodules which arose in the cirrhotic livers of rats fed p-dimethylaminoazobenzene (p-DAB). The cells of which they were composed were similar in most respects to those described in Part I of this series. An increase in free cytoplasmic ribosomes, prominence of the Golgi apparatus in the perinuclear area, microfilament bundles and abnormal microbodies were the most notable features observed. It is concluded that the 4 nodules and the 3 microscopic foci described in Part I may represent different stages of the same proliferative process. The possible precancerous significance of the nodules remains to be established.

S. Afr. Med. J., 48, 1290 (1974).

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eISSN: 2078-5135
print ISSN: 0256-9574