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A comparison of the effects of no radrenaline, adrenaline and some phenylephrine derivatives on alpha-, betal " and beta2- adrenergic receptors
Abstract
The possibility of two types of beta-adrenergic receptors is supported by the results presented. It is shown that the phenylephrine group of compounds have more pronounced affinities towards the beta,-(cardiac) adrenergic receptors than towards the beta,-(bronchial) adrenergic receptors. The cardioselective action is the greatest in the case of ethylnorphenylephrine. It is postulated that the presence of a small substituent on the amino nitrogen and a (only one) meta-hydroxyl group may contribute towards cardioselectivity in the case of phenylethylam;ne derivatives. Ethylnorphenylephrine has a relatively low affinity towards the alpha-adrenergic receptors.
