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Prediction of amikacin dose requirements in neutropenic patients with haematological disease


C.S. Zent
R Allin
P.I. Folb

Abstract

This study reports on the use of an easily applied Bayesian forecasting programme (OPT; Clyde-soft) to predict amikacin dose requirements in 10 patients with haematological disease and neutropenic fever. OPT-determined dose adjustment achieved therapeutic drug levels for 80% of the peak and 94% of the trough measurements.


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eISSN: 2078-5135
print ISSN: 0256-9574