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In vitro activity of a new 'higher-lactam' antibacterial agent LY 193239
Abstract
In vitro activity ofthe new bicyclic pyrazolidinone LY 193239 (Eli Lilly) was evaluated against 52 clinical isolates of Haemophilus influenzae (4 were β-lactamase producers), 32 Enterococcus faecalis, 14 Neisseria gonorrhoeae (1 β-lactamasepositive) and 19 Neisseria meningitidis. Activity was best against Neisseria spp. and H. influenzae, including penicillinase- producing strains. Results of the time-kill study against a non-enzyme-mediated penicillin resistant strain of N. meningitidis indicate that exposure to an antibacterial concentration four times the minimal inhibitory concentration was bactericidal. E. faecalis was insensitive.
