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Jun 13, 2017Article Details
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Main Article Content
Protein prenylation – its general significance and particular relevance to endocrinology and bone metabolism
Abstract
The cholesterol synthetic pathway gives rise to farnesyl and geranylgeranyl, which are incorporated into cytosolic proteins, the prenylated proteins. The processes involved in prenylation and the functions of the prenylated proteins, including Ras, Rab, Rho and Rac, are reviewed. The use of prenylation inhibitors in anti-cancer therapy and the role of prenylation in endocrinology and bone and mineral metabolism are briefly discussed. The potential effect of the hydroxy-methyl-glutaryl coenzyrne A(HMG-CoA) reductase inhibitors on prenylated proteins and in particular the potential beneficial effect on bone is highlighted.
