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The management of peptic ulcer disease in the 1990s


JA Louw
IN Marks

Abstract

Perceptions regarding the effective management of peptic ulcer disease have changed dramq,tically over the past few years. Healing of the ulcer crater is no longer a problem and the real challenge of management is now the prevention of the almost inevitable ulcer relapse. While the pathogenetic model Cif acid-pepsin aggression versus mucosal resistance has provided a rationale for the use of either acid-inhibitory or mucosal-protective therapy for ulcer healing, peptic ulcers are .now increasingly being seen as Helicobacter py/ori-related (the majority), NSAIDrelated (an important minority) and, less commonly, purely 'acid-related'.' Acceptance of thed'e aetiological factors now provides the basis for an effective short- and long-term management strategy for peptic ulcer disease.

SAMJ Volume 85 No.6 June 1995

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eISSN: 2078-5135
print ISSN: 0256-9574