Article Sidebar
Published:
Oct 2, 2008Article Details
Copyright remains in the Author’s name. The work is licensed under a Creative Commons Attribution - Noncommercial Works License. Authors are required to complete and sign an Author Agreement form that outlines Author and Publisher rights and terms of publication. The Agreement form should be uploaded along with other submissions files and any submission will be considered incomplete without it [forthcoming].
Material submitted for publication in the SAMJ is accepted provided it has not been published or submitted for publication elsewhere. Please inform the editorial team if the main findings of your paper have been presented at a conference and published in abstract form, to avoid copyright infringement. The SAMJ does not hold itself responsible for statements made by the authors.
Previously published images
If an image/figure has been previously published, permission to reproduce or alter it must be obtained by the authors from the original publisher and the figure legend must give full credit to the original source. This credit should be accompanied by a letter indicating that permission to reproduce the image has been granted to the author/s. This letter should be uploaded as a supplementary file during submission.
Main Article Content
Antioxidant and oxidative stress status in type 2 diabetes and diabetic foot ulcer
Abstract
Objectives: Oxidative stress (OS) has been implicated in the aetiology and progression of diabetic complications including diabetic foot ulcer. In the present study, the levels of lipid peroxides (LPO), a marker of lipid peroxidation and 8-hydroxy-2\'-deoxyguanosine (8-OHdG), a marker of DNA damage as well as the enzymatic antioxidant activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) in type 2 diabetes mellitus and diabetic foot ulcer subjects were assessed and compared with apparently healthy normal subjects in order to understand the involvement of OS in diabetic foot ulcer subject.
Design: The above-mentioned OS markers were measured in 50 subjects for each of the following groups: type 2 diabetes mellitus (DM), diabetic foot ulcer (DF) and non diabetic control (NC).
Results: Significant elevated values of LPO and 8-OHdG were found in DM subjects: 39.86% and 45.53% increase respectively compared to the NC subjects. This increase in both parameters was greater for DF subjects: 80.23% and 53.91% respectively. SOD activities were significantly reduced in DM (14.82%) and DF (4.09%) subjects in contrast with elevated activities of GPx observed in DM (21.87%) and DF (20.94%) subjects. In this study, positive correlations between glycated hemoglobin/fasting plasma glucose (HbA1c/FPG) and the following OS parameters: LPO, 8-OHdG and GPx were observed. However, correlation between the above glycemic components and SOD was found to be negative.
Conclusion: Increased oxidation subsequent to diabetic conditions induces an overexpression of GPx activity suggesting a compensatory mechanism by the body to prevent further tissue damage in these subjects.
South African Medical Journal Vol. 98 (8) 2008: pp. 614-617
