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Treating AIDS-associated cerebral toxoplasmosis – pyrimethamine plus sulfadiazine compared with cotrimoxazole, and outcome with adjunctive glucocorticoids


J Arens
K Barnes
N Crowley
G Maartens

Abstract



We conducted a retrospective study of AIDS-associated cerebral toxoplasmosis. Eighteen patients received pyrimethamine plus sulfadiazine and 25 co-trimoxazole, with comparable baseline characteristics. There were no differences in clinical outcomes,
but co-trimoxazole was better tolerated (p = 0.066). There was also a trend towards more deaths among patients who received glucocorticoids.

South African Medical Journal Vol. 97 (10) 2007: pp. 956-958

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eISSN: 2078-5135
print ISSN: 0256-9574