Article Sidebar
Published:
May 21, 2013Article Details
Issue
Section
Articles
Material submitted for publication in the South African Medical Journal (SAMJ) is accepted provided it has not been published elsewhere. Copyright forms will be sent with acknowledgement of receipt and the SAMJ reserves copyright of the material published. The SAMJ does not hold itself responsible for statements made by the authors.
Main Article Content
Ten-year survival of patients with oesophageal squamous cell carcinoma
Abstract
Objectives. The standard predictive factors of actuarial survival such as T and N stage become less important as patients live for more than 10
years after treatment of cancer. Reports of actual 10-year survivors of oesophageal squamous cell carcinoma (SCC) are rare, and demographic
and clinicopathological factors associated with 10-year survival have not been well documented. In this research we evaluated factors predictive
of actual, as opposed to actuarial, 10-year survival.
Methods. We retrospectively analysed 1 046 patients who had undergone oesophagectomy for oesophageal SCC. The demographic and clinicopathological characteristics of patients who were alive more than 10 years after oesophagectomy and those of patients who had died
were compared.
Results. Univariate analysis showed that 18 factors differed significantly between the two groups. Based on logistic regression analysis, factors associated with 10-year survival were younger age, female gender, absence of dysphagia, a left transthoracic surgical approach, lower
pathological T stage, and fewer metastatic lymph nodes.
Conclusion. The independent positive predictors of actual as opposed to actuarial 10-year survival are younger age, female gender, absence of
dysphagia, lower pathological T stage, and fewer metastatic lymph nodes.
years after treatment of cancer. Reports of actual 10-year survivors of oesophageal squamous cell carcinoma (SCC) are rare, and demographic
and clinicopathological factors associated with 10-year survival have not been well documented. In this research we evaluated factors predictive
of actual, as opposed to actuarial, 10-year survival.
Methods. We retrospectively analysed 1 046 patients who had undergone oesophagectomy for oesophageal SCC. The demographic and clinicopathological characteristics of patients who were alive more than 10 years after oesophagectomy and those of patients who had died
were compared.
Results. Univariate analysis showed that 18 factors differed significantly between the two groups. Based on logistic regression analysis, factors associated with 10-year survival were younger age, female gender, absence of dysphagia, a left transthoracic surgical approach, lower
pathological T stage, and fewer metastatic lymph nodes.
Conclusion. The independent positive predictors of actual as opposed to actuarial 10-year survival are younger age, female gender, absence of
dysphagia, lower pathological T stage, and fewer metastatic lymph nodes.
