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Nephrogenic systemic fibrosis (NSF) and gadolinium-based contrast media
Abstract
Nephrogenic systemic fibrosis (NSF), unknown before March 1997 and first described in 2000, is a systemic disorder characterised by widespread tissue fibrosis. The first known case occurred in 1997, after the use of gadolinium-based contrast agents (GBCAs) at high doses in patients with renal failure had become routine. An overwhelming majority occurred within weeks to months after injection of a GBCA. The link between nephrogenic
systemic fibrosis (NSF) and GBCAs was recognised in 2006. This note comprises guidelines on the prevention of NSF.
systemic fibrosis (NSF) and GBCAs was recognised in 2006. This note comprises guidelines on the prevention of NSF.